The goal of the DECARB research project is to investigate mixes of policy instruments that would allow Switzerland to respect its climate commitments and reach the net-zero emissions target by 2050. In this context, we focus on energy-related emissions which stem from four sectors, namely: power generation, transport, buildings and industry. We evaluate various policy measures, as well as combinations thereof, along several dimensions relevant to policymakers, including environmental effectiveness, economic efficiency, and political feasibility. We adopt complementary methods to perform our analyses in this regard. First, we derive lessons on climate policy design from the existing scientific literature. Second, we employ an augmented numerical simulation model to quantify the economic effects of full-decarbonization pathways for Switzerland. Third, we investigate public support for various policy measures by Swiss residents thanks to a stated-preference survey. Our analyses reveal that a strong case can be made for mixes of policy instruments if Switzerland is to reach climate neutrality by 2050. Indeed, once real-world complexities are taken into account, the superiority once granted to carbon pricing as a stand-alone measure to abate greenhouse gas emissions is compromised. Indeed, carefully combining policy instruments has the potential for substantial positive synergies in a number of respects, thereby offering an opportunity to improve climate policy. Importantly, desirable mixes of policy instruments are found to differ across sectors, given the distinct targeted technologies and agents. The corresponding results have been presented at international conferences and resulted in four working papers, to be submitted and eventually published in peer-reviewed journals. The key findings and policy recommendations ensuing from the DECARB research project are provided in the form of three policy briefs.