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research article

Exploiting correlations across trials and behavioral sessions to improve neural decoding

Zhang, Yizi
•
Lyu, Hanrui
•
Hurwitz, Cole
Show more
2025
Neuron

Traditional neural decoders link neural activity to behavior within single trials of a session, overlooking correlations across trials and sessions. However, animals show similar neural patterns when performing the same task, and their behaviors are influenced by prior experiences. To capture these dependencies, we introduce two complementary models: a multi-session reduced-rank regression model that shares behaviorally relevant neural structure across sessions and a multi-session state-space model that captures behavioral structure across trials and sessions. On 433 sessions spanning 270 brain regions in the International Brain Laboratory (IBL) mouse Neuropixels dataset, our decoders outperform traditional approaches on four behaviors, with results generalizing across datasets, species, and tasks. Unlike deep learning methods, our models are efficient and interpretable, providing low-dimensional neural representations, task-related single-neuron contributions, and brain-wide timescales of neural activation.

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Type
research article
DOI
10.1016/j.neuron.2025.10.026
Scopus ID

2-s2.0-105025167854

PubMed ID

41308644

Author(s)
Zhang, Yizi

Columbia University

Lyu, Hanrui

Northwestern University

Hurwitz, Cole

Columbia University

Wang, Shuqi  

École Polytechnique Fédérale de Lausanne

Findling, Charles

The International Brain Laboratory

Wang, Yanchen

Columbia University

Hubert, Felix

Université de Genève

Pouget, Alexandre

The International Brain Laboratory

Varol, Erdem

NYU Tandon School of Engineering

Paninski, Liam

Columbia University

Date Issued

2025

Published in
Neuron
Subjects

decision-making

•

electrophysiology

•

interpretable models

•

multi-session modeling

•

neural decoding

•

Neuropixels recordings

•

reduced-rank regression

•

state-space models

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LCN1  
Available on Infoscience
December 29, 2025
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/257357
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