An efficient total synthesis of K-13, a non-competitive inhibitor of ACE I
An efficient synthesis of K-13 (I), a non-competitive inhibitor of ACE I with an endo biaryl ether bond, is described. The key cycloetherification reaction of linear tripeptide II gave a 17-membered macrocycle in quant. yield. [on SciFinder (R)]
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Bigot, A., Bois-Choussy, M., & Zhu, J. (2000). An efficient total synthesis of K-13, a non-competitive inhibitor of ACE I. Tetrahedron Letters, 41(23), 4573–4577. https://doi.org/10.1016/S0040-4039(00)00695-X
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2000
41
23
4573
4577
CAN 133:223013
34-3
Amino Acids, Peptides, and Proteins
Institut de Chimie des Substances Naturelles, CNRS,Gif-sur-Yvette,Fr.
Journal
written in English.
17355-19-0; 188624-33-1; 244769-35-5; 291781-71-0 Role: RCT (Reactant), RACT (Reactant or reagent) (total synthesis of the 17-membered cyclopeptide K-13 as a non-competitive inhibitor of ACE I); 118493-33-7P; 291781-64-1P; 291781-65-2P; 291781-66-3P; 291781-67-4P; 291781-68-5P; 291781-69-6P; 291781-70-9P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (total synthesis of the 17-membered cyclopeptide K-13 as a non-competitive inhibitor of ACE I); 108890-90-0P; 291781-72-1P Role: SPN (Synthetic preparation), PREP (Preparation) (total synthesis of the 17-membered cyclopeptide K-13 as a non-competitive inhibitor of ACE I)
REVIEWED
OTHER