Formal [4+1] Cycloaddition of o ‐Aminobenzyl Chlorides with Isocyanides: Synthesis of 2‐Amino‐3‐Substituted Indoles
Reaction of substituted o-aminobenzyl chlorides with isocyanides in the presence of a weak base (NaHCO3) at room temperature afforded the diversely functionalized 2-aminoindoles in good to excellent yields. A formal [4+1] cycloaddition of the in situ generated aza-ortho-xylylenes with isocyanides accounted for the reaction outcome.
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Jong, J. A. W., Bao, X., Wang, Q., & Zhu, J. (2019). Formal [4+1] Cycloaddition of o ‐Aminobenzyl Chlorides with Isocyanides: Synthesis of 2‐Amino‐3‐Substituted Indoles. Helvetica Chimica Acta, 102(3), Article e1900002. https://doi.org/10.1002/hlca.201900002
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2019
102
3
e1900002
REVIEWED
EPFL
| Funder | Grant Number |
FNS | FNS |