Preparation of ecteinascidin alkaloids, such as ecteinascidins 583 and 597
The present invention concerns an intermediate of the following formula I in which R 1 and R 2 represent independently of each other a C 1 -C 12 alkyl group, a (C 1 -C 12 alkoxy)carbonyl group, optionally substituted by one, two or three halogen atom, a (C 2 -C 12 alkenyloxy) carbonyl group, an acyl group, a aryl(C 1 -C 12 )alkyl group, an arylalkoxy carbonyl group, a (C 1 -C 12 alkyl)sulfonyle group or an arylsulfonyl group and R 3 represents a O-protecting group. The present invention concerns also a process of preparation of the intermediate and its use for the preparation of Ecteinascidin 743 and Ecteinascidin-770.
Cite this item
Zhu, J., Bois-Choussy, M., Chen, J., & Chen, X. (2007). Preparation of ecteinascidin alkaloids, such as ecteinascidins 583 and 597 (Patent No. AT554093). https://infoscience.epfl.ch/handle/20.500.14299/58423
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37899253
CAN 146:462418
31-6
Alkaloids
Patent
written in English.
20070426
200132-54-3 Role: CAT (Catalyst use), USES (Uses) (asym. synthesis of ecteinascidin alkaloids, such as ecteinascidins 583 and 597); 106-95-6; 121-33-5; 488-17-5; 533-31-3 (1,3-Benzodioxol-5-ol); 620-72-4; 645-33-0; 924-44-7; 2799-07-7; 2937-50-0; 17763-80-3; 49757-42-8; 81477-94-3; 102308-32-7; 934969-73-0 Role: RCT (Reactant), RACT (Reactant or reagent) (asym. synthesis of ecteinascidin alkaloids, such as ecteinascidins 583 and 597); 69404-94-0P; 111726-43-3P; 114899-80-8P (Ecteinascidin 770); 184300-08-1P (Ecteinascidin 583); 244126-22-5P; 244126-41-8P; 259220-89-8P; 308359-33-3P; 366020-68-0P; 366020-69-1P; 402469-27-6P; 686776-20-5P; 686776-22-7P; 686776-23-8P; 686776-24-9P; 686776-25-0P; 686776-27-2P; 854022-02-9P; 874758-51-7P; 874758-53-9P; 874758-54-0P; 874758-55-1P; 874758-56-2P; 874758-58-4P; 874758-59-5P; 874758-60-8P; 874758-61-9P; 874758-62-0P; 874758-63-1P; 874758-64-2P; 874758-65-3P; 874758-66-4P; 874758-67-5P; 874758-68-6P; 874758-69-7P; 874758-70-0P; 874758-71-1P; 874758-72-2P; 874758-73-3P; 874758-74-4P; 874758-76-6P; 874758-78-8P; 874758-82-4P; 925451-68-9P; 925451-73-6P; 925451-75-8P; 925451-76-9P; 925451-77-0P; 925451-78-1P; 925451-79-2P; 925451-80-5P; 925451-84-9P; 925451-85-0P; 925451-86-1P; 925451-87-2P; 925451-88-3P; 925451-89-4P; 925451-91-8P; 925451-92-9P; 925451-95-2P; 925451-96-3P; 925451-97-4P; 934969-68-3P; 934969-69-4P; 934969-71-8P; 934969-72-9P; 934969-74-1P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (asym. synthesis of ecteinascidin alkaloids, such as ecteinascidins 583 and 597); 114899-77-3P (Ecteinascidin 743); 184300-07-0P (Ecteinascidin 597); 934969-70-7P Role: SPN (Synthetic preparation), PREP (Preparation) (asym. synthesis of ecteinascidin alkaloids, such as ecteinascidins 583 and 597)
A2
US
2005-728295
20051020
Alternative title(s) : (de) Zwischenprodukt und verfahren zur herstellung von ecteinascidin aus diesem zwischenprodukt (fr) Intermédiaire et procédé de préparation de l'ectéinascidine utilisant un tel intermédiaire (en) Intermediate and process of preparation of ecteinascidin using such intermediate
Application: WO WO, (Centre National de la Recherche Scientifique, Fr.).
| Identifier | Country code | Kind code | Date issued |
AT554093 | AT | T | 2012-05-15 |
EP1937689 | EP | B1 | 2012-04-18 |
US8058435 | US | B2 | 2011-11-15 |
US2009171080 | US | A1 | 2009-07-02 |
JP2009512662 | JP | A | 2009-03-26 |
EP1937689 | EP | A2 | 2008-07-02 |
WO2007045686 | WO | A3 | 2007-07-12 |
EP1792904 | EP | A1 | 2007-06-06 |
WO2007045686 | WO | A2 | 2007-04-26 |
CA2626595 | CA | A1 | 2007-04-26 |