The hydraulic design, computational analysis, and experimental investigations of a high-speed small-scale turbopump for mobile waste heat recovery applications based on organic Rankine cycle systems are presented in this paper. Such applications demand high-pressure rise, lightweight, and compact pumping systems with simple construction. The investigated turbopump features an unshrouded 37.75 mm tip diameter single-stage centrifugal pump equipped with eight radial blades, eight splitters blades, and a rectangular axisymmetric volute. The pump should deliver 0.28 kg/s of mass flow rate with a pressure rise of 20 bar at a designed rotational speed of 25,000 rpm. Due to uncertainties observed in employing state-of-the-art 1-d methods that are valid for much larger machines, computational fluid dynamics is utilized to obtain a design meeting the specifications. The pump’s performance is evaluated experimentally at different rotational speeds, mass flow rates, and impeller tip clearances. The excellent agreement between experimental data and predictions from computational fluid dynamics validates the design methodology and computational results. The turbopump’s characteristics are then utilized to estimate the possible performance improvement of a target organic Rankine cycle using the novel turbopump instead of a commercial multi-stage centrifugal pump. The comparison suggests that the novel turbopump increases the efficiency of the target organic Rankine cycle by 0.3 % points and decreases its back-work ratio by nearly 50 %. The novel turbopump is approximately ten times more compact compared to commercial systems.