Regeneration of urban areas from neighborhoods in transition to innovative components. Research at the LAST aims to contribute to transitions towards sustainability in the built environment by integrating environmental, socio-cultural, and economic parameters in the architectural project. The research projects fall within the broader context of quality; they focus on supporting the emergence of new knowledge, revealing the potential for innovation potential that can be transposed into architectural production, and identifying optimization processes of construction. Translating the general concept of sustainability into concrete terms, the LAST approach is based on a holistic, interdisciplinary, and evaluative method by searching convergent strategies at the different scales of intervention for the architect, from the neighborhood to the building component. To reflect this approach, we present two research projects at both ends of the scales’ spectrum: RHODANIE URBAINE region, city, and neighborhood scales and WORKING SPACE building and components scales. Concrete results are shown through project models along with multicriteria evaluations.