This study leverages a Discrete Event Simulation (DES) model to optimize the sweet potato supply chain in Zimbabwe, focusing on production, distribution, and market dynamics under varying climate conditions. The integration of climate data into the simulation model reveals significant insights into the resilience of different sweet potato varieties, particularly highlighting the suitability of yellow-skinned sweet potatoes for harsh climates due to their high resilience and drought resistance. However, market preferences still favor white-skinned varieties despite their vulnerability to climate extremes. The DES model identifies key bottlenecks, particularly in cultivation and transportation, that hinder supply chain efficiency. To address these challenges, the study emphasizes the importance of targeted interventions, such as improving access to irrigation, strengthening pest management, and adopting community-based resource-sharing approaches. These strategies are critical for enhancing both the resilience and efficiency of the supply chain. Additionally, the study highlights the urgent need for adaptive strategies to mitigate the effects of drought on agricultural productivity, especially in regions that heavily rely on crops like sweet potatoes. Overall, this research offers strategic insights for policymakers and stakeholders aiming to improve food security and agricultural productivity in Zimbabwe, as well as in other countries with similar climate challenges.