A system for full-field laser Doppler blood flow imaging has been developed and tested on biomedical samples. The new imaging system allows 2D flow maps or monitoring flux signals to be obtained from a plurality of measured points simultaneously by using a 2D array of photodetectors. The detection part of the system is based on an intelligent CMOS camera with a built-in digital signal processor and memory. The imaging time of the system is as much as to 4 times faster than for the conventional scanning laser Doppler imager. The performance of the system was evaluated in vitro and in vivo. The first measurement results with this new system on human skin are reported. (C) 2005 Optical Society of America.