A method for removal of N-Boc protecting groups from substrates on TFA-sensitive resins
N-tert-butyloxycarbonyl (Boc) groups can be removed from peptides supported on Rink's amide resin by treatment with trimethylsilyl triflate/2,6-lutidine. This methodol. was illustrated here with syntheses of several peptides, but it is likely to be used more extensively in solid phase syntheses of small mol. libraries. [on SciFinder (R)]
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Zhang, A. J., Russell, D. H., Zhu, J., & Burgess, K. (1998). A method for removal of N-Boc protecting groups from substrates on TFA-sensitive resins. Tetrahedron Letters, 39(41), 7439–7442. https://doi.org/10.1016/S0040-4039(98)01631-1
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1998
39
41
7439
7442
CAN 129:331039
34-3
Amino Acids, Peptides, and Proteins
Department Chemistry,Texas A&M University,College Station,TX,USA.
Journal
written in English.
108-48-5 (2,6-Lutidine); 27607-77-8 (Trimethylsilyl triflate) Role: RCT (Reactant), RACT (Reactant or reagent) (using trimethylsilyl triflate/lutidine for Boc deprotection of peptides bound to TFA-sensitive resins); 60117-24-0P; 64190-70-1P; 215094-76-1P; 215094-77-2P; 215094-78-3P; 215094-79-4P; 215094-80-7P; 215094-81-8P; 215094-82-9P; 215094-83-0P Role: SPN (Synthetic preparation), PREP (Preparation) (using trimethylsilyl triflate/lutidine for Boc deprotection of peptides bound to TFA-sensitive resins)
REVIEWED
OTHER