This contribution introduces an experimental study aiming to provide concrete evidence on how façade and daylight pattern geometry can affect the emotional responses triggered by a space. The study was conducted in Virtual Reality (VR) where participants were exposed to 360° scenes of an interior space with three different façade patterns. Their subjective evaluations and heart rate were recorded. The results show a statistically significant effect of façade on the perception of space, as well as the mean heart rate change. Specifically, during exposure to a façade with an irregular pattern, participants rated the space as more interesting and their mean heart rate was lower, resulting to a greater mean heart rate change compared to the resting state, providing quantifiable measures of the impact of façade characteristics on human perception and physiological behavior.