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  4. Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model
 
research article

Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model

Khandelwal, Preeti J.
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Dumanis, Sonya B.
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Feng, Li Rebekah
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2010
Molecular neurodegeneration

α-Synuclein aggregates in Lewy bodies and plays a central role in the pathogenesis of a group of neurodegenerative disorders, known as "Synucleinopathies", including Parkinson's disease. Parkin mutations result in loss of parkin E3-ubiquitin ligase activity and cause autosomal recessive early onset parkinsonism.

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