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research article

An Implantable Wireless System for Remote Hemodynamic Monitoring of Heart Failure Patients

Besirli, Mustafa  
•
Ture, Kerim  
•
Beghetti, Maurice
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August 1, 2023
Ieee Transactions On Biomedical Circuits And Systems

This article presents an implantable wireless system for remote hemodynamic monitoring, which enables direct, continuous (24/7), and simultaneous measurement of pulmonary arterial pressure (PAP) and cross-sectional area (CSA) of the artery. The implantable device, which measures 3.2 mm x 2 mm x 10 mm, comprises a piezoresistive pressure sensor, an ASIC implemented in 180-nm CMOS, a piezoelectric ultrasound (US) transducer, and a nitinol anchoring loop. An energy-efficient pressure monitoring system, which employs duty-cycling and spinning excitation technique, achieves 0.44 mmHg resolution in a pressure range from -135 mmHg to +135 mmHg and consumes 1.1 nJ conversion energy. The artery diameter monitoring system utilizes the inductive characteristic of the implant's anchoring loop and achieves 0.24 mm resolution within a diameter range of 20 mm to 30 mm, four times higher than echocardiography lateral resolution. The wireless US power and data platform enables simultaneous power and data transfer employing a single piezoelectric transducer in the implant. The system is characterized with an 8.5 cm tissue phantom and achieves a US link efficiency of 1.8%. The uplink data is transmitted by using an ASK modulation scheme parallel to the power transfer and achieves a modulation index of 26%. The implantable system is tested in an in-vitro experimental setup, which emulates the arterial blood flow, and accurately detects fast pressure peaks for systolic and diastolic pressure changes at both 1.28 MHz and 1.6 MHz US powering frequencies, with corresponding uplink data rates of 40 kbps and 50 kbps.

  • Details
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Type
research article
DOI
10.1109/TBCAS.2023.3273711
Web of Science ID

WOS:001083108000005

Author(s)
Besirli, Mustafa  
Ture, Kerim  
Beghetti, Maurice
Maloberti, Franco
Dehollain, Catherine  
Mattavelli, Marco  
Barrettino, Diego Ruben  
Date Issued

2023-08-01

Published in
Ieee Transactions On Biomedical Circuits And Systems
Volume

17

Issue

4

Start page

688

End page

700

Subjects

Technology

•

Asic

•

Cmos

•

Energy-Efficient

•

Hemodynamic Monitoring

•

Heart Failure

•

Implantable Medical Devices

•

Inductive Sensor

•

Pressure Sensor

•

Remote Patient Monitoring

•

Readout Ic

•

Ultrasonic Powering

•

Ultrasonic Communication

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
SCI-STI-MM  
FunderGrant Number

Swiss National Science Foundation (SNSF)

CRSII5 180272/1

Swiss National Science Foundation (SNF)

CRSII5_180272

Available on Infoscience
February 16, 2024
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/203843
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