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research article

Toward video-rate compressive spontaneous Raman imaging via single-photon avalanche diode arrays

Gentner, Clemence
•
Burri, Samuel  
•
Charbon, Edoardo  
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November 15, 2024
Optics Letters

Spontaneous Raman microscopy is well-known for its remarkable chemical contrast yet suffers from slow acquisition speeds. Recently, the compressive Raman microspectroscopy framework has shown that a significant speed advantage is brought by leveraging shot-noise-limited detection using a single-photon avalanche diode (SPAD). However, current imaging speeds of compressive Raman architectures are fundamentally limited by SPAD sensitivity and dead time. Here, we demonstrate an efficient and scalable compressive Raman parallelization scheme based on SPAD arrays. We show that parallelization using line excitation, instead of spatial multiplexing, allows to reach effective pixel dwell times (tau pdt) of 0.8 mu s. Such fast speed represents over one order-of-magnitude speed-up over previous demonstrations. This effective parallelization not only allows for demonstrating unprecedented chemical imaging speeds using the otherwise weak spontaneous Raman effect but also paves the way for true video-rate inexpensive molecular microspectroscopy. (c) 2024 Optica Publishing Group. All rights, including for text and data mining (TDM), Artificial Intelligence (AI) training, and similar technologies, are reserved.

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Type
research article
DOI
10.1364/OL.538993
Web of Science ID

WOS:001378676900001

PubMed ID

39546722

Author(s)
Gentner, Clemence

Universite PSL

Burri, Samuel  

École Polytechnique Fédérale de Lausanne

Charbon, Edoardo  

École Polytechnique Fédérale de Lausanne

Bruschini, Claudio  

École Polytechnique Fédérale de Lausanne

de Aguiar, Hilton B.

Universite PSL

Date Issued

2024-11-15

Publisher

Optica Publishing Group

Published in
Optics Letters
Volume

49

Issue

22

Start page

6573

End page

6576

Subjects

IN-VIVO

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
AQUA  
FunderFunding(s)Grant NumberGrant URL

Sorbonne Universite (Emergence)

Available on Infoscience
January 27, 2025
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/245383
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