Mesoscopic light-sheet fluorescence imaging for drug delivery and target engagement assessment
Fluorescence lifetime imaging (FLIM) offers a powerful approach for assessing drug delivery and target engagement in targeted therapies. However, monitoring drug response in 3D at the mesoscopic scale has been largely constrained by tissue scattering and prolonged acquisition times. In this study, we present the application of our near-infrared to shortwave-infrared (NIR-SWIR) light-sheet mesoscope for rapid 3D Förster Resonance Energy Transfer (FRET) mapping in HER2-positive tumor spheroid models.
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Chavez, L., Erbas, I., Crosbourne, I., Ragab, S., Pandey, V., Bruschini, C. E., Charbon, E., Barroso, M., & Intes, X. R. (2026). Mesoscopic light-sheet fluorescence imaging for drug delivery and target engagement assessment. In X. Intes, M. Ochoa, & M. A. Yaseen (Editors), Multimodal Biomedical Imaging XXI. 21st Multimodal Biomedical Imaging (BIOS 2026), San Francisco, United States, January 17, 2026. https://doi.org/10.1117/12.3080933
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Rensselaer Polytechnic Institute
Rensselaer Polytechnic Institute
Albany Medical Center Hospital
Rensselaer Polytechnic Institute
École Polytechnique Fédérale de Lausanne
Rensselaer Polytechnic Institute
2026-03-05
Proceedings; 13841
11
REVIEWED
EPFL
| Event name | Event acronym | Event place | Event date |
BIOS 2026 | San Francisco, United States | 2026-01-17 - 2026-01-23 | |