Landslides as secondary seismic effects are causing some patterns of soil failure that are often considered among the most destructive ones. In fact, the impact from triggered landslides has sometimes exceeded damage directly related to strong shaking and fault rupture. The objective of this research study is landslide hazard and risk assessment considering different water saturation and earthquake scenarios, for a selected area in a sub-urban hilly part of Skopje-the capital of Macedonia. The final product is represented by digital maps of expected permanent displacements for a defined earthquake scenario, in different water saturation conditions of the instable soil layer. Qualitative landslide risk assessment is performed taking into consideration the exposure map of the habitants and local road of the area. As to the target area, it can be concluded that it has the potential for instability that, under certain scenarios, could result in economic and social damage (vulnerability of individual houses, vulnerability of infrastructure and alike). The results from this study referring to potentially affected population and infrastructure present solid base for preventive mitigation activities for reducing the consequences of geotechnical hazards in Skopje City associated with earthquakes.