Continuous monitoring of electrodermal activity (EDA) through wearable devices has attracted much attention in recent times. However, the persistent challenge demands analog front-end (AFE) systems with high sensitivity, low power consumption, and minimal calibration requirements to ensure practical usability in wearable technologies. In response to this challenge, this research introduces VCO-CARE, a VoltageControlled Oscillator-based Analog Readout tailored for continuous EDA sensing. The results show that our system achieves an exceptional average sensitivity of up to 40 pS within a 0−20μS range and a negligible relative error of less than 0.0025% for fixed-resistance. Furthermore, the proposed system consumes only an average of 2.3μ W based on post-layout validations and introduces a low noise contribution, measuring only 0.8μ Vrms across the 0−1.5 Hz EDA signal band. This research aims to drive the evolution of wearable sensors characterized by seamless adaptability to diverse users, minimal power consumption, and outstanding noise resilience.