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research article

Complex viscosity of polyhyaluronic acid

Pulatsu, E.
•
Kanso, M. A.
•
Chakraborty, R.  
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March 1, 2025
Physics Of Fluids

We use the macromolecular moments method of Chakraborty et al. [Phys Fluids, 34, 093109 (2022)] to calculate the complex viscosity of an aqueous suspension of polyhyaluronic acid. We do so by first calculating the equilibrium structure of the macromolecule, which leads us to its principal moments of inertia. Inserting these moments into the main results of general rigid bead-rod theory, yields from first principles, the complex viscosity of an aqueous suspension of polyhyaluronic acid. For polyhyaluronic, we find that one bead of a shish-kebab corresponds to one monomer of polyhyaluronic. Comparing our results with published complex viscosity measurements on polyhyaluronic acid suspensions, uncovers good agreement, and even better agreement with hydrodynamic interaction.

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Type
research article
DOI
10.1063/5.0259252
Web of Science ID

WOS:001441552700014

Author(s)
Pulatsu, E.

University of Ottawa

Kanso, M. A.

Massachusetts Institute of Technology (MIT)

Chakraborty, R.  

École Polytechnique Fédérale de Lausanne

Giacomin, A. J.

Peking University

Date Issued

2025-03-01

Publisher

AIP Publishing

Published in
Physics Of Fluids
Volume

37

Issue

3

Article Number

033116

Subjects

HYALURONIC-ACID

•

CONFINED GEOMETRIES

•

DELIVERY-SYSTEMS

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DRUG-DELIVERY

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DERMAL FILLER

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MEDICINE

•

DERIVATIVES

•

HYDROGELS

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DYNAMICS

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RHEOLOGY

•

Science & Technology

•

Technology

•

Physical Sciences

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
SCI-STI-JVH  
FunderFunding(s)Grant NumberGrant URL

Natural Sciences and Engineering Research Council of Canada10.13039/501100000038

Natural Sciences and Engineering Research Council of Canada (NSERC)

Natural Sciences and Engineering Research Council of Canada (NSERC)

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Available on Infoscience
March 19, 2025
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/248012
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