MR device (100) comprising a miniaturized magnetic resonance system (101) and a cell culture chamber (502) for the analysis of biological samples of less than about 1000 µm in size, wherein said device (100) is at least partially covered by a passivation-binding layer (800). The invention also concerns a method for manufacturing said device (100), comprising a step of depositing a thin passivation-binding layer (800) on said system (101) The depositing step is preferably performed through a deposition process selected from chemical vapor deposition and physical vapor deposition.