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  4. Slice Estimation in Diffusion MRI of Neonatal and Fetal Brains in Image and Spherical Harmonics Domains Using Autoencoders
 
conference paper

Slice Estimation in Diffusion MRI of Neonatal and Fetal Brains in Image and Spherical Harmonics Domains Using Autoencoders

Kebiri, Hamza
•
Girard, Gabriel  
•
Aleman-Gomez, Yasser
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January 1, 2022
Computational Diffusion Mri (Cdmri 2022)
13th International Workshop on Computational Diffusion MRI (CDMRI)

Diffusion MRI (dMRI) of the developing brain can provide valuable insights into the white matter development. However, slice thickness in fetal dMRI is typically high (i.e., 3-5 mm) to freeze the in-plane motion, which reduces the sensitivity of the dMRI signal to the underlying anatomy. In this study, we aim at overcoming this problem by using autoencoders to learn unsupervised efficient representations of brain slices in a latent space, using raw dMRI signals and their spherical harmonics (SH) representation. We first learn and quantitatively validate the autoencoders on the developing Human Connectome Project pre-term newborn data, and further test the method on fetal data. Our results show that the autoencoder in the signal domain better synthesized the raw signal. Interestingly, the fractional anisotropy and, to a lesser extent, the mean diffusivity, are best recovered in missing slices by using the autoencoder trained with SH coefficients. A comparison was performed with the same maps reconstructed using an autoencoder trained with raw signals, as well as conventional interpolation methods of raw signals and SH coefficients. From these results, we conclude that the recovery of missing/corrupted slices should be performed in the signal domain if the raw signal is aimed to be recovered, and in the SH domain if diffusion tensor properties (i.e., fractional anisotropy) are targeted. Notably, the trained autoencoders were able to generalize to fetal dMRI data acquired using a much smaller number of diffusion gradients and a lower b-value, where we qualitatively show the consistency of the estimated diffusion tensor maps.

  • Details
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Type
conference paper
DOI
10.1007/978-3-031-21206-2_1
Web of Science ID

WOS:000907760200001

Author(s)
Kebiri, Hamza
Girard, Gabriel  
Aleman-Gomez, Yasser
Yu, Thomas  
Jakab, Andras
Canales-Rodriguez, Erick Jorge  
Cuadra, Meritxell Bach  
Date Issued

2022-01-01

Publisher

SPRINGER INTERNATIONAL PUBLISHING AG

Publisher place

Cham

Published in
Computational Diffusion Mri (Cdmri 2022)
ISBN of the book

978-3-031-21205-5

978-3-031-21206-2

Series title/Series vol.

Lecture Notes in Computer Science

Volume

13722

Start page

3

End page

13

Subjects

Computer Science, Artificial Intelligence

•

Computer Science, Interdisciplinary Applications

•

Radiology, Nuclear Medicine & Medical Imaging

•

Computer Science

•

super-resolution

•

autoencoders

•

spherical harmonics

•

diffusion tensor imaging

•

pre-term

•

fetal

•

brain

•

mri

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LTS5  
Event nameEvent placeEvent date
13th International Workshop on Computational Diffusion MRI (CDMRI)

Singapore, SINGAPORE

Sep 22, 2022

Available on Infoscience
February 27, 2023
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/195272
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