research article
Comment on "Circadian rhythms in the absence of the clock gene Bmal1"
April 16, 2021
Ray et al. (Reports, 14 February 2020, p. 800) recently claimed temperature-compensated, free-running mRNA oscillations in Bmal1(-/-) liver slices and skin fibroblasts. We reanalyzed these data and found far fewer reproducible mRNA oscillations in this genotype. We also note errors and potentially inappropriate analyses.
Cite this item
Abruzzi, K. C., Gobet, C., Naef, F., & Rosbash, M. (2021). Comment on “Circadian rhythms in the absence of the clock gene Bmal1”. Science, 372(6539), Article eabf0922. https://doi.org/10.1126/science.abf0922
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Type
research article
Web of Science ID
WOS:000641286700002
Author(s)
Date Issued
2021-04-16
Published in
Volume
372
Issue
6539
Article Number
eabf0922
Editorial or Peer reviewed
REVIEWED
Written at
EPFL
EPFL units
Available on Infoscience
June 5, 2021
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