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research article

Sequencing by Hybridization of Long Targets

Qin, Yu
•
Schneider, Tobias M  
•
Brenner, Michael P
2012
PLoS One

Sequencing by Hybridization (SBH) reconstructs an n-long target DNA sequence from its biochemically determined l-long subsequences. In the standard approach, the length of a uniformly random sequence that can be unambiguously reconstructed is limited to n = O(2(l)) due to repetitive subsequences causing reconstruction degeneracies. We present a modified sequencing method that overcomes this limitation without the need for different types of biochemical assays and is robust to error.

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Type
research article
DOI
10.1371/journal.pone.0035819
PubMed ID

22574124

Author(s)
Qin, Yu
Schneider, Tobias M  
Brenner, Michael P
Date Issued

2012

Published in
PLoS One
Volume

7

Issue

5

Article Number

e35819

Subjects

DNA

•

DNA Probes

•

DNA Probes: genetics

•

DNA: genetics

•

DNA: methods

•

Nucleic Acid

•

Nucleic Acid Hybridization

•

Nucleic Acid Hybridization: methods

•

Repetitive Sequences

•

Sequence Analysis

Note

Editor: Gibas, Cynthia

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
ECPS  
Available on Infoscience
December 7, 2015
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/121532
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