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patent

Preparation of beta-amino or alpha ,beta-diamino esters derived from serine

Zhu, Jieping  
•
Couturier, Cedric
•
Blanchet, Jerome
2006

The invention relates to the prepn. of esters R1R2NCH2CH(Nu)CO2R3 (R1-R3 are protecting groups and Nu is a nucleophilic group) by reaction of R1R2NCH(CH2-Y)CO2R3 (Y is a leaving group) with a nucleophile. Thus, treatment of (R)-Bn2NCH(CH2O3SMe)CO2Me with NaN3 in MeCN afforded 90% (S)-Bn2NCH2CH(N3)CO2Me. [on SciFinder (R)]

  • Details
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Type
patent
EPO Family ID

35544328

Author(s)
Zhu, Jieping  
Couturier, Cedric
Blanchet, Jerome
Subjects

Amino acids Role: RCT (Reactant)

•

SPN (Synthetic preparation)

•

PREP (Preparation)

•

RACT (Reactant or reagent) (esters

•

prepn. of beta -amino or alpha

•

beta -diamino esters derived from serine)

•

Asymmetric synthesis and induction

•

Nucleophiles (prepn. of beta -amino or alpha

•

beta -diamino esters derived from serine)

•

serine ester beta amino deriv asym synthesis

Note

CAN 145:397788, 34-2, Amino Acids, Peptides, and Proteins, Patent, written in French., 20061012, 55-21-0 (Benzamide); 56-45-1 (L-Serine); 67-51-6 (3,5-Dimethylpyrazole); 75-64-9; 95-48-7 (o-Cresol); 98-10-2 (Benzenesulfonamide); 103-49-1 (Dibenzylamine); 105-34-0 (Methyl cyanoacetate); 105-53-3 (Diethyl malonate); 105-56-6 (Ethyl cyanoacetate); 106-40-1 (4-Bromoaniline); 108-59-8 (Dimethyl malonate); 108-68-9 (3,5-Dimethylphenol); 108-95-2 (Phenol); 108-98-5 (Thiophenol); 109-73-9 (n-Butylamine); 109-77-3 (Malononitrile); 109-97-7 (Pyrrole); 110-89-4 (Piperidine); 110-91-8 (Morpholine); 120-72-9 (Indole); 122-39-4 (Diphenylamine); 123-75-1 (Pyrrolidine); 123-90-0 (Thiomorpholine); 142-08-5 (2-Hydroxypyridine); 143-33-9 (Sodium cyanide); 150-76-5 (4-Methoxyphenol); 151-50-8 (Potassium cyanide); 288-13-1 (Pyrazole); 288-32-4 (Imidazole); 288-88-0 (1H-1,2,4-Triazole); 497-25-6 (2-Oxazolidinone); 616-45-5 (2-Pyrrolidinone); 1534-08-3; 2577-48-2; 2577-90-4; 2759-28-6 (N-Benzylpiperazine); 15803-02-8 (1-Methyl-4-bromopyrazole); 35161-71-8 (Methylprop-2-ynylamine); 202478-34-0; 219986-64-8 (3-Trifluoromethyl-5-(p-tolyl)-1H-pyrazole); 630389-88-7 Role: RCT (Reactant), RACT (Reactant or reagent) (prepn. of beta -amino or alpha ,beta -diamino esters derived from serine); 888957-31-1P; 911404-06-3P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. of beta -amino or alpha ,beta -diamino esters derived from serine); 888957-42-4P; 888957-43-5P; 911404-03-0P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of beta -amino or alpha ,beta -diamino esters derived from serine), A2, FR, 2005-3537, 20050408

Alternative title(s) : (fr) Procede de preparation de ß-aminoesters ou a-, ß-diaminoesters derives de la serine (en) Method for preparing $g(b)-amino esters or $g(a)-, $g(b)-diamino esters derived from serine

Application: WO WO, (Shasun Pharma Solutions Limited, UK; Centre National de la Recherche Scientifique (C.N.R.S))

EPFL units
LPMV  
LNNME  
LSPN  
IdentifierCountry codeKind codeDate issued

WO2006106244

WO

A3

2007-09-13

FR2884249

FR

A1

2006-10-13

WO2006106244

WO

A2

2006-10-12

Available on Infoscience
November 25, 2010
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/58439
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