The relative stability of hexanuclear Pd-based coordination cages has been investigated. For this purpose, we have synthesized eight cages of type [Pd6L12]12+ or [Pd6L8]12+. Six of these cages have been described before, and two are reported here for the first time, including crystallographic analyses. The stability of the cages was investigated by subjecting cage solutions in DMSO-d6 or CD3CN to different amounts of pyridine. The cage degradation was monitored by 1H NMR. Our findings reveal significant variability in cage stability. The relative thermodynamic stability of the cages varies by nearly two orders of magnitude and the kinetic stability by more than four orders of magnitude. The stability of the cages is primarily governed by the nature of the donor group, with denticity playing a subordinate role. The high kinetic stability conferred by imidazole-based ligands provided access to a rare octanuclear cage of the type [Pd8L16]16+, featuring a square antiprismatic geometry.