We prove local (in space and time) well-posedness for a mildly regularised version of the stochastic quantisation of the Yukawa(2) Euclidean field theory with a self-interacting boson. Our regularised dynamic is still singular but avoids non-local divergences, allowing us to use a version of the Da Prato-Debussche argument (Da Prato and Debussche in Ann Probab 31(4):1900-1916, 2003. https://doi.org/10.1214/aop/1068646370). This model is a test case for a non-commutative probability framework for formulating the kind of singular SPDEs arising in the stochastic quantisation of field theories mixing both bosons and fermions.