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review article

Palladium-Catalyzed Functionalization of Olefins and Alkynes: From Oxyalkynylation to Tethered Dynamic Kinetic Asymmetric Transformations (DYKAT)

Nicolai, Stefano  
•
Orcel, Ugo  
•
Muriel, Bastian  
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November 10, 2020
Synlett

This review presents an account of the palladium-catalyzed functionalizations of alkenes and alkynes developed at the Laboratory of Catalysis and Organic Synthesis (LCSO). Starting from the intramolecular oxy- and aminoalkynylation of alkenes, tethered methods were then developed to functionalize allylic amines and alcohols, as well as propargylic amines. Finally, a new dynamic kinetic asymmetric transformation was developed based on the use of a 'one-arm' Trost-type ligand, giving access to enantiopure amino alcohols. Each section is a personal account by the researcher(s) who performed the work. 1 Introduction, 2 Oxy- and Aminoalkynylation of Olefins, 3 In Situ Tethering Strategies for the Synthesis of Vicinal Amino Alcohols and Diamines, 4 Carboamination of Allylic Alcohols, 5 Carbooxygenation of Propargylic Amines, 6 Enantioselective Carboetherification/Hydrogenation via a Catalytically Formed Chiral Auxiliary, 7 Conclusion

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Synlett2021-472GreenAccess1.pdf

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Synlett2021-472GreenAccess.pdf

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2021-11-10

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CC BY-NC

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