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research article

An in vivo study of the orientation-dependent and independent components of transverse relaxation rates in white matter

Gil, Rita
•
Khabipova, Diana  
•
Zwiers, Marcel
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2016
NMR in Biomedicine

Diffusion-weighted imaging (DWI) provides information that allows the estimation of white-matter (WM) fibre orientation and distribution, but it does not provide information about myelin density, fibre concentration or fibre size within each voxel. On the other hand, quantitative relaxation contrasts (like the apparent transverse relaxation, R2∗) offer iron and myelin-related contrast, but their dependence on the orientation of microstructure with respect to the applied magnetic field, B0 , is often neglected. The aim of this work was to combine the fibre orientation information retrieved from the DWI acquisition and the sensitivity to microstructural information from quantitative relaxation parameters. The in vivo measured quantitative transverse relaxation maps (R2 and R2∗) were decomposed into their orientation-dependent and independent components, using the DWI fibre orientation information as prior knowledge. The analysis focused on major WM fibre bundles such as the forceps major (FMj), forceps minor (FMn), cingulum (CG) and corticospinal tracts (CST). The orientation-dependent R2 parameters, despite their small size (0-1.5 Hz), showed higher variability across different fibre populations, while those derived from R2∗, although larger (3.1-4.5 Hz), were mostly bundle-independent. With this article, we have, for the first time, attempted the in vivo characterization of the orientation-(in)dependent components of the transverse relaxation rates and demonstrated that the orientation of WM fibres influences both R2 and R2∗ contrasts.

  • Details
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Type
research article
DOI
10.1002/nbm.3616
Web of Science ID

WOS:000389141000012

Author(s)
Gil, Rita
Khabipova, Diana  
Zwiers, Marcel
Hilbert, Tom
Kober, Tobias  
Marques, José P.
Date Issued

2016

Publisher

Wiley-Blackwell

Published in
NMR in Biomedicine
Volume

29

Issue

12

Start page

1780

End page

1790

Subjects

CIBM-AIT

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
CIBM  
LIFMET  
Available on Infoscience
December 13, 2016
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/131945
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