In order to fully exploit the potential of renewable energy resources (RERs) for building applications, opti- mal design and control of the different energy systems is a compelling challenge to address. This paper presents a two-step multi-objective optimization approach to size both thermal and electrical energy systems in regard of thermo-economic performance indicators to suit consumer and grid operator inter- ests. Several utilities such as storage, conversion systems, and RERs are hence modeled and formulated through mixed-integer linear programming. Simultaneously, the algorithm defines the optimal opera- tion strategy, based on a model predictive control structure, for each deterministic unit embedded within the energy management system of the building to meet the different comfort and service requirements. The developed design framework is successfully applied on several energy systems configuration of typical Swiss building types. Different component sizes are analyzed, regarding the present investment cost and the self-consumption share. In addition, this paper presents a novel optimal design criteria based on the maximum cost benefits in the view of both the consumer and the distribution network operator.