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  4. Resonant Doppler flow imaging and optical vivisection of retinal blood vessels
 
research article

Resonant Doppler flow imaging and optical vivisection of retinal blood vessels

Bachmann, A. H.
•
Villiger, M. L.
•
Blatter, C.  
Show more
2007
Optics Express

For Fourier domain optical coherence tomography any sample movement during camera integration causes blurring of interference fringes and as such reduction of sensitivity for flow detection. The proposed method overcomes this problem by phase-matching a reference signal to the sample motion. The interference fringes corresponding to flow signal will appear frozen across the detector whereas those of static sample structures will be blurred resulting in enhanced contrast for blood vessels. An electro-optic phase modulator in the reference arm, driven with specific phase cycles locked to the detection frequency, allows not only for qualitative but also for quantitative flow detection already from the relative signal intensities. First applications to extract in-vivo retinal flow and to visualize 3D vascularization, i.e. optical vivisection, are presented.

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Type
research article
DOI
10.1364/OE.15.000408
Web of Science ID

WOS:000244680600018

Author(s)
Bachmann, A. H.
Villiger, M. L.
Blatter, C.  
Lasser, T.  
Leitgeb, R. A.
Date Issued

2007

Published in
Optics Express
Volume

15

Issue

2

Start page

408

End page

422

Subjects

(110.4500) Imaging systems

•

Optical coherence tomography

•

(110.6880) Imaging systems

•

Three-dimensional image acquisition

•

(170.3880) Medical optics and biotechnology

•

Medical and biological imaging

•

(170.4470) Medical optics and biotechnology

•

Ophthalmology

•

(170.4500) Medical optics and biotechnology

•

Optical coherence tomography

Editorial or Peer reviewed

REVIEWED

Written at

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Available on Infoscience
February 25, 2008
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/19105
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