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  4. Experimental And Theoretical Insight Into Formulations Based On Poly(Vinyl Alcohol Boric Acid) And Diclofenac Sodium Salt
 
research article

Experimental And Theoretical Insight Into Formulations Based On Poly(Vinyl Alcohol Boric Acid) And Diclofenac Sodium Salt

Irimiciuc, Stefan-Andrei
•
Ianus, Gelu
•
Agop, Maricel
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January 1, 2020
University Politehnica Of Bucharest Scientific Bulletin-Series A-Applied Mathematics And Physics

A series of three formulations were prepared in view of experimental and theoretical investigation of their drug release potential. The morphology of the film formulations, in terms of distribution of drug into the polymeric matrix and the nature of the drug was investigated by scanning electron microscopy and polarized light microscopy techniques. The in vitro drug release has been studied in a medium mimicking the physiological medium. It was established that the drug release is in close correlation with the mass ratio. Assuming that the dynamics of polymer-drug system's structural units take place on continuous and nondifferentiable curves (multifractal curves), we show that in a one-dimensional hydrodynamic formalism of multifractal variables the drug release mechanism (Fickian diffusion, non-Fickian diffusion, etc) are given through synchronous dynamics at a differentiable and non-differentiable scale resolutions. Finally, the model is confirmed by the empirical data.

  • Details
  • Metrics
Type
research article
Web of Science ID

WOS:000555516500020

Author(s)
Irimiciuc, Stefan-Andrei
Ianus, Gelu
Agop, Maricel
Crumpei Tanasa, Irina
Paun, Maria-Alexandra  
Mandalian, Tigran-Lucian
Crumpei, Julia
Paun, Vladimir-Alexandru
Paun, Viorel-Puiu
Date Issued

2020-01-01

Publisher

UNIV POLITEHNICA BUCHAREST, SCI BULL

Published in
University Politehnica Of Bucharest Scientific Bulletin-Series A-Applied Mathematics And Physics
Volume

82

Issue

3

Start page

219

End page

230

Subjects

Mathematics, Applied

•

Physics, Multidisciplinary

•

Mathematics

•

Physics

•

poly(vinyl alcohol boric acid)

•

diclofenac

•

drug release

•

multifractal model

•

boric-acid

•

polyvinyl-alcohol

•

composites

•

matrix

•

chitosan

•

behavior

•

release

•

systems

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
SCI-STI-CD  
Available on Infoscience
August 15, 2020
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/170877
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