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  4. lifex-ep: a robust and efficient software for cardiac electrophysiology simulations
 
research article

lifex-ep: a robust and efficient software for cardiac electrophysiology simulations

Africa, Pasquale Claudio
•
Piersanti, Roberto
•
Regazzoni, Francesco
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October 13, 2023
Bmc Bioinformatics

Background: Simulating the cardiac function requires the numerical solution of multi-physics and multi-scale mathematical models. This underscores the need for streamlined, accurate, and high-performance computational tools. Despite the dedicated endeavors of various research teams, comprehensive and user-friendly software programs for cardiac simulations, capable of accurately replicating both normal and pathological conditions, are still in the process of achieving full maturity within the scientific community.|Results: This work introduces life(x)-ep, a publicly available software for numerical simulations of the electrophysiology activity of the cardiac muscle, under both normal and pathological conditions. life(x)-ep employs the monodomain equation to model the heart's electrical activity. It incorporates both phenomenological and second-generation ionic models. These models are discretized using the Finite Element method on tetrahedral or hexahedral meshes. Additionally, life(x)-ep integrates the generation of myocardial fibers based on Laplace-Dirichlet Rule-Based Methods, previously released in Africa et al., 2023, within life(x)-fiber. As an alternative, users can also choose to import myofibers from a file. This paper provides a concise overview of the mathematical models and numerical methods underlying life(x)-ep, along with comprehensive implementation details and instructions for users. life(x)-ep features exceptional parallel speedup, scaling efficiently when using up to thousands of cores, and its implementation has been verified against an established benchmark problem for computational electrophysiology. We showcase the key features of life(x)-ep through various idealized and realistic simulations conducted in both normal and pathological scenarios. Furthermore, the software offers a user-friendly and flexible interface, simplifying the setup of simulations using self-documenting parameter files.|Conclusions: life(x)-ep provides easy access to cardiac electrophysiology simulations for a wide user community. It offers a computational tool that integrates models and accurate methods for simulating cardiac electrophysiology within a high-performance framework, while maintaining a user-friendly interface. life(x)-ep represents a valuable tool for conducting in silico patient-specific simulations.

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Type
research article
DOI
10.1186/s12859-023-05513-8
Web of Science ID

WOS:001129863300001

Author(s)
Africa, Pasquale Claudio
Piersanti, Roberto
Regazzoni, Francesco
Bucelli, Michele
Salvador, Matteo
Fedele, Marco
Pagani, Stefano
Dede, Luca
Quarteroni, Alfio  
Date Issued

2023-10-13

Publisher

BMC

Published in
Bmc Bioinformatics
Volume

24

Issue

1

Start page

389

Subjects

Life Sciences & Biomedicine

•

Cardiac Electrophysiology

•

Computational Cardiology

•

High-Performance Computing

•

Mathematical Modeling

•

Finite Element Method

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
CIB  
FunderGrant Number

European Research Council (ERC) under the European Union

740132

Available on Infoscience
February 20, 2024
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/204815
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