There is growing concern about rubber-derived compounds (RDCs), predominantly originating from tire and road wear particles. Other consumer products, including sports equipment, also contain RDCs, and human exposure to these compounds is of particular interest due to demonstrated toxicity to animal species. In this study, we investigated RDCs intentionally incorporated into climbing shoes for enhanced performance. We found high concentrations of 15 RDCs in shoe sole samples (Σ 15 RDCs: 25− 3405 μg/g), aerosol particulate matter (Σ 15 RDCs: 2.6−37 μg/g), and settled dust (Σ 15 RDCs: 1.5−55 μg/g) in indoor climbing halls. The estimated daily intake via inhalation/ingestion of Σ 15 RDCs for climbers and employees in some of these facilities ranged from 1.7 to 48 ng/kg/day, exceeding known intake levels of RDCs from other sources. Abrasion powder resulting from friction between climbing shoes and footholds is the likeliest source of high concentrations of RDCs observed in aerosol particulate matter and settled dust. These findings reveal a previously unknown human exposure route of RDCs.