Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. Safety, tolerability and blinding efficiency of non-invasive deep transcranial temporal interference stimulation: first experience from more than 250 sessions
 
Loading...
Thumbnail Image
research article

Safety, tolerability and blinding efficiency of non-invasive deep transcranial temporal interference stimulation: first experience from more than 250 sessions

Vassiliadis, Pierre  
•
Stiennon, Emma
•
Windel, Fabienne  
Show more
April 1, 2024
Journal Of Neural Engineering

Objective. Selective neuromodulation of deep brain regions has for a long time only been possible through invasive approaches, because of the steep depth-focality trade-off of conventional non-invasive brain stimulation (NIBS) techniques. Approach. An approach that has recently emerged for deep NIBS in humans is transcranial Temporal Interference Stimulation (tTIS). However, a crucial aspect for its potential wide use is to ensure that it is tolerable, compatible with efficient blinding and safe. Main results. Here, we show the favorable tolerability and safety profiles and the robust blinding efficiency of deep tTIS targeting the striatum or hippocampus by leveraging a large dataset (119 participants, 257 sessions), including young and older adults and patients with traumatic brain injury. tTIS-evoked sensations were generally rated as 'mild', were equivalent in active and placebo tTIS conditions and did not enable participants to discern stimulation type. Significance. Overall, tTIS emerges as a promising tool for deep NIBS for robust double-blind, placebo-controlled designs.

  • Details
  • Metrics
Type
research article
DOI
10.1088/1741-2552/ad2d32
Web of Science ID

WOS:001182198300001

Author(s)
Vassiliadis, Pierre  
•
Stiennon, Emma
•
Windel, Fabienne  
•
Wessel, Maximilian J.
•
Beanato, Elena  
•
Hummel, Friedhelm Christoph  
Date Issued

2024-04-01

Publisher

Iop Publishing Ltd

Published in
Journal Of Neural Engineering
Volume

21

Issue

2

Article Number

024001

Subjects

Technology

•

Life Sciences & Biomedicine

•

Safety

•

Blinding

•

Sensations

•

Temporal Interference Stimulation

•

Non-Invasive Brain Stimulation

•

Striatum

•

Hippocampus

Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPHUMMEL  
FunderGrant Number

Horizon Europe Research & Innovation Programme

101092612

Swiss National Science Foundation (SNSF

320030L_197899

Defitech Foundation (NiN-Park, Morges, CH)

Show more
Available on Infoscience
April 3, 2024
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/206905
Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés