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  4. Segregated Algorithms for the Numerical Simulation of Cardiac Electromechanics in the Left Human Ventricle
 
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Segregated Algorithms for the Numerical Simulation of Cardiac Electromechanics in the Left Human Ventricle

Dede', L.
•
Gerbi, A.
•
Quarteroni, A.  
January 1, 2020
Mathematics Of Mechanobiology

We propose and numerically assess three segregated ( partitioned) algorithms for the numerical solution of the coupled electromechanics problem for the left human ventricle. We split the coupled problem into its core mathematical models and we proceed to their numerical approximation. Space and time discretizations of the core problems are carried out by means of the Finite Element Method and Backward Differentiation Formulas, respectively. In our mathematical model, electrophysiology is represented by the monodomain equation while the Holzapfel-Ogden strain energy function is used for the passive characterization of tissue mechanics. A transmurally variable active strain model is used for the active deformation of the fibers of the myocardium to couple the electrophysiology and the mechanics in the framework of the active strain model. In this work, we focus on the numerical strategy to deal with the solution of the coupled model, which is based on novel segregated algorithms that we propose. These also allow using different time discretization schemes for the core submodels, thus leading to the formulation of staggered algorithms, a feature that we systematically exploit to increase the efficiency of the overall computational procedure. By means of numerical tests we show that these staggered algorithms feature (at least) first order of accuracy. We take advantage of the efficiency of the segregated schemes to solve, in a High Performance Computing framework, the cardiac electromechanics problem for the human left ventricle, for both idealized and subject-specific configurations.

  • Details
  • Metrics
Type
book part or chapter
DOI
10.1007/978-3-030-45197-4_3
Web of Science ID

WOS:000556127300004

Author(s)
Dede', L.
Gerbi, A.
Quarteroni, A.  
Date Issued

2020-01-01

Publisher

SPRINGER INTERNATIONAL PUBLISHING AG

Publisher place

Cham

Published in
Mathematics Of Mechanobiology
ISBN of the book

978-3-030-45197-4

978-3-030-45196-7

Start page

81

End page

116

Series title/Series vol.

Lecture Notes in Mathematics

Volume
2260
Subjects

Biophysics

•

Mathematical & Computational Biology

•

fluid-structure interaction

•

active-strain

•

stress-distribution

•

model

•

heart

•

monodomain

•

activation

•

electrophysiology

•

architecture

•

contraction

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
CMCS  
CIB  
Available on Infoscience
August 20, 2020
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/170956
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