The PETALE experimental programme in the CROCUS reactor intends to provide integral measurements to constrain stainless steel nuclear data. This article presents the tools and the methodology developed to design and optimize the experiments, and its operating principle. Two acceleration techniques have been implemented in the Serpent2 code to perform a Total Monte Carlo uncertainty propagation using variance reduction and correlated sampling technique. Their application to the estimation of the expected reaction rates in dosimeters is also discussed, together with the estimation of the impact of the nuisance parameters of aluminium used in the experiment structures.