A new application in the nano-biosensing field gives proof that the coupling of nanofabricated wires exhibiting mem- ristive electrical characteristics and DNA-aptamers, may provide definitely innovative nano-bio-sensors for ultrasensitive label-free detection of cancer biomarkers, as well as, for effective screening of therapeutic compounds. This scheme, paves the way to a holistic approach where both the diagnosis and therapeutics can be taken into consideration.