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  4. Sub-Lethal Peak Exposure to Insecticides Triggers Olfaction-Mediated Avoidance in Zebrafish Larvae
 
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research article

Sub-Lethal Peak Exposure to Insecticides Triggers Olfaction-Mediated Avoidance in Zebrafish Larvae

Koenemann, Sarah  
•
Meyer, Stephanie
•
Betz, Alexander
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September 7, 2021
Environmental Science & Technology

In agricultural areas, insecticides inevitably reach water bodies via leaching or run-off. While designed to be neurotoxic to insects, insecticides have adverse effects on a multitude of organisms due to the high conservation of the nervous system among phyla. To estimate the ecological effects of insecticides, it is important to investigate their impact on nontarget organisms such as fish. Using zebrafish as the model, we investigated how different classes of insecticides influence fish behavior and uncovered neuronal underpinnings of the associated behavioral changes, providing an unprecedented insight into the perception of these chemicals by fish. We observed that zebrafish larvae avoid diazinon and imidacloprid while showing no response to other insecticides with the same mode of action. Moreover, ablation of olfaction abolished the aversive responses, indicating that fish smelled the insecticides. Assessment of neuronal activity in 289 brain regions showed that hypothalamic areas involved in stress response were among the regions with the largest changes, indicating that the observed behavioral response resembles reactions to stimuli that threaten homeostasis, such as changes in water chemistry. Our results contribute to the understanding of the environmental impact of insecticide exposure and can help refine acute toxicity assessment.

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Type
research article
DOI
10.1021/acs.est.1c01792
Web of Science ID

WOS:000695530700039

Author(s)
Koenemann, Sarah  
•
Meyer, Stephanie
•
Betz, Alexander
•
Zupanic, Anze
•
vom Berg, Colette
Date Issued

2021-09-07

Published in
Environmental Science & Technology
Volume

55

Issue

17

Start page

11835

End page

11847

Subjects

Engineering, Environmental

•

Environmental Sciences

•

Engineering

•

Environmental Sciences & Ecology

•

insecticide exposure

•

behavioral response

•

olfaction

•

neuronal activity

•

stress response

•

induced oxidative stress

•

rainbow-trout

•

coregonus-clupeaformis

•

locomotor repertoire

•

lateral habenula

•

coho salmon

•

behavior

•

cadmium

•

responses

•

neurons

Peer reviewed

REVIEWED

Written at

EPFL

Available on Infoscience
September 25, 2021
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/181675
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