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  4. Breathe in and straighten your back: Hypoxia, notch, and scoliosis
 
research article

Breathe in and straighten your back: Hypoxia, notch, and scoliosis

Bajard, L.
•
Oates, A. C.  
2012
Cell

In this issue of Cell, Sparrow et al. propose a new mechanism for sporadically occurring congenital scoliosis in which Notch signaling and hypoxia converge in the embryo on somite patterning via the segmentation clock. This interaction between hypoxia and a predisposed genetic background might underlie other birth defects with incomplete penetrance. © 2012 Elsevier Inc.

  • Details
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Type
research article
DOI
10.1016/j.cell.2012.03.024
Scopus ID

2-s2.0-84859776115

Author(s)
Bajard, L.
Oates, A. C.  
Date Issued

2012

Published in
Cell
Volume

149

Issue

2

Start page

255

End page

256

Subjects

cell death

•

embryo pattern formation

•

fibroblast growth factor

•

gene locus

•

gene mutation

•

genetic predisposition

•

genotype environment interaction

•

genotype phenotype correlation

•

human

•

hypoxia

•

mesoderm

•

nonhuman

•

Notch receptor

•

penetrance

•

priority journal

•

Review

•

scoliosis

•

somite

•

transcription factor

•

transcription factor HES7

•

transcription factor MESP2

•

unclassified drug

•

Wnt protein

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
UPOATES  
Available on Infoscience
May 30, 2017
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/137758
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