Since the development of porous materials, porous organic polymers (POPs) have received much attention due to advantages such as attractive architecture, large pore volume, high surface area, and immense porosity. Furthermore, their porous structure can be functionalized with multiple chemical reagents, which will improve their performances in various applications. In the past, significant efforts have been made to synthesize POPs via Friedel-Crafts reaction. It is easy to handle and operates under mild synthesis conditions, requires low reaction temperature, uses considerably less expensive chemicals, and produces high-yield POPs with desirable surface areas. POPs prepared via this method act competitively in various fields. This review focuses on the recent applications of the POPs introduced in gas adsorption and separation, catalyst, water treatment, biomedical, and electrochemical applications, aiming to pave the way for researchers to develop new POPs for modern applications.