This thesis presents a measurement of charm mixing and CP-violation parameters using D0 -> K0S pi+ pi- decays. These mixing parameters include the mass and decay-width differences of the mass eigenstates of the D0-D0bar system. A search for Charge-Parity violation is performed through measurements of D0-D0b mixing and of the interference between mixing and decay amplitudes. The dataset consists of events reconstructed in proton-proton collisions collected by the LHCb experiment during the operation of the Large Hadron Collider (LHC) from 2016 to 2018. This sample corresponds to an integrated luminosity of 5.4 fb^-1. The D0 decays are selected in semileptonically decays of b hadrons. The results are expressed in terms of the CP-averaged mixing parameters and CP-violating differences as x_cp= (+4.29 +/- 1.48 (stat) +/- 0.26 (syst)) x 10^{-3} y_cp= (+12.61 +/- 3.12 (stat) +/- 0.83 (syst)) x 10^{-3} delta x= (-0.77 +/- 0.93 (stat) +/- 0.28 (syst)) x 10^{-3} delta y= (+3.01 +/- 1.92 (stat) +/- 0.26 (syst)) x 10^{-3} where the first uncertainty is statistical and the second is systematic. They correspond to the mixing and CP-violation parameters

x = 0.46^{+0.15}{-0.16} x 10^{-2} y = 1.24^{+0.32}{-0.33} x 10^{-2} |q/p| = 1.21^{+0.21}{-0.15} \phi = -0.132^{+0.088}{-0.120} rad.

The value of x deviates from zero with a significance of almost 3 sigma. These results are complementary to and consistent with previous measurements and with the current world-average values. They represent an independent and complementary knowledge of the charm-mixing parameters. A combination with the recent LHCb analysis of Dstar -> D0 (->K0S pi+ pi-) pi decays is also reported.