Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. Advancing Thalamic Nuclei Segmentation: The Impact of Compressed Sensing on MRI Processing
 
research article

Advancing Thalamic Nuclei Segmentation: The Impact of Compressed Sensing on MRI Processing

Hubner, Sebastian
•
Tambalo, Stefano
•
Novello, Lisa
Show more
December 15, 2024
Human Brain Mapping

The thalamus is a collection of gray matter nuclei that play a crucial role in sensorimotor processing and modulation of cortical activity. Characterizing thalamic nuclei non-invasively with structural MRI is particularly relevant for patient populations with Parkinson's disease, epilepsy, dementia, and schizophrenia. However, severe head motion in these populations poses a significant challenge for in vivo mapping of thalamic nuclei. Recent advancements have leveraged the compressed sensing (CS) framework to accelerate structural MRI acquisition times in MPRAGE sequence variants, while fast segmentation tools like FastSurfer have reduced processing times in neuroimaging research. In this study, we evaluated thalamic nuclei segmentations derived from six different MPRAGE variants with varying degrees of CS acceleration (from about 9 to about 1-min acquisitions). Thalamic segmentations were initialized from either FastSurfer or FreeSurfer, and the robustness of the thalamic nuclei segmentation tool to different initialization inputs was evaluated. Our findings show minimal sequence effects with no systematic bias, and low volume variability across sequences for the whole thalamus and major thalamic nuclei. Notably, CS-accelerated sequences produced less variable volumes compared to non-CS sequences. Additionally, segmentations of thalamic nuclei initialized from FastSurfer and FreeSurfer were highly comparable. We provide the first evidence supporting that a good segmentation quality of thalamic nuclei with CS T1-weighted image acceleration in a clinical 3T MRI system is possible. Our findings encourage future applications of fast T1-weighted MRI to study deep gray matter. CS-accelerated sequences and rapid segmentation methods are promising tools for future studies aiming to characterize thalamic nuclei in vivo at 3T in both healthy individuals and clinical populations.

  • Details
  • Metrics
Type
research article
DOI
10.1002/hbm.70120
Web of Science ID

WOS:001382847500001

PubMed ID

39722224

Author(s)
Hubner, Sebastian

University of Trento

Tambalo, Stefano

University of Trento

Novello, Lisa

Fondazione Bruno Kessler

Hilbert, Tom  

École Polytechnique Fédérale de Lausanne

Kober, Tobias  

École Polytechnique Fédérale de Lausanne

Jovicich, Jorge

University of Trento

Date Issued

2024-12-15

Publisher

Wiley

Published in
Human Brain Mapping
Volume

45

Issue

18

Article Number

e70120

Subjects

compressed sensing MRI

•

fast MRI acquisition

•

FastSurfer

•

FreeSurfer

•

segmentation

•

thalamic nuclei

•

volumetric characterization

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
SIEMENS-HC
LTS5  
FunderFunding(s)Grant NumberGrant URL

Municipality of Rovereto

Municipality of the City of Rovereto (Trento), Italy

Universita degli Studi di Trento, as part of the Wiley - CRUI-CARE agreement

Available on Infoscience
January 28, 2025
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/245857
Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés