As business conditions change rapidly, the need for integrating business and technical systems calls for novel ICT frameworks and solutions to remain concurrent in highly competitive markets. A number of problems and issues arise in this regard. In this paper, four big challenges of enterprise Information systems (EIS) are defined and discussed: (1) data value chain management; (2) context awareness; (3) usability, interaction and visualization; and (4) human learning and continuous education. Major contributions and research orientations of ICT technologies are elaborated based on selected key issues and lessons learned. First, the semantic mediator is proposed as a key enabler for dealing with semantic interoperability. Second, the context-aware infrastructures are proposed as a main solution for making efficient use of EIS to offer a high level of customization of delivered services and data. Third, the product avatar is proposed as a contribution to an evolutionary social, collaborative and product-centric and interaction metaphor with EIS. Fourth, human learning solutions are considered to develop individual competences in order to cope with new technological advances. The paper ends with a discussion on the impact of the proposed solutions on the economic and social landscape and proposes a set of recommendations as a perspective towards next generation of information systems. (C) 2015 Elsevier B.V. All rights reserved.