research article
Formal [4+1] Cycloaddition of o ‐Aminobenzyl Chlorides with Isocyanides: Synthesis of 2‐Amino‐3‐Substituted Indoles
Reaction of substituted o-aminobenzyl chlorides with isocyanides in the presence of a weak base (NaHCO3) at room temperature afforded the diversely functionalized 2-aminoindoles in good to excellent yields. A formal [4+1] cycloaddition of the in situ generated aza-ortho-xylylenes with isocyanides accounted for the reaction outcome.
Type
research article
Author(s)
Jong, Jacobus A. W.
Bao, Xu
Wang, Qian
Zhu, Jieping
Date Issued
2019
Publisher
Published in
Volume
102
Issue
3
Article Number
e1900002
Editorial or Peer reviewed
REVIEWED
Written at
EPFL
EPFL units
| Funder | Grant Number |
FNS | FNS |
Available on Infoscience
May 3, 2019
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