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  4. Iron-carbohydrate complexes treating iron anaemia: Understanding the nano-structure and interactions with proteins through orthogonal characterisation
 
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research article

Iron-carbohydrate complexes treating iron anaemia: Understanding the nano-structure and interactions with proteins through orthogonal characterisation

Krupnik, Leonard
•
Avaro, Jonathan
•
Liebi, Marianne  
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April 1, 2024
Journal Of Controlled Release

Intravenous (IV) iron-carbohydrate complexes are widely used nanoparticles (NPs) to treat iron deficiency anaemia, often associated with medical conditions such as chronic kidney disease, heart failure and various inflammatory conditions. Even though a plethora of physicochemical characterisation data and clinical studies are available for these products, evidence-based correlation between physicochemical properties of ironcarbohydrate complexes and clinical outcome has not fully been elucidated yet. Studies on other metal oxide NPs suggest that early interactions between NPs and blood upon IV injection are key to understanding how differences in physicochemical characteristics of iron-carbohydrate complexes cause variance in clinical outcomes. We therefore investigated the core-ligand structure of two clinically relevant iron-carbohydrate complexes, iron sucrose (IS) and ferric carboxymaltose (FCM), and their interactions with two structurally different human plasma proteins, human serum albumin (HSA) and fibrinogen, using a combination of cryo-scanning transmission electron microscopy (cryo-STEM), x-ray diffraction (XRD), small-angle x-ray scattering (SAXS)

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Type
research article
DOI
10.1016/j.jconrel.2024.02.044
Web of Science ID

WOS:001225857800001

Author(s)
Krupnik, Leonard
•
Avaro, Jonathan
•
Liebi, Marianne  
•
Anaraki, Neda Iranpour
•
Kohlbrecher, Joachim
•
Sologubenko, Alla
•
Handschin, Stephan
•
Rzepiela, Andrzej J.
•
Appel, Christian
•
Totu, Tiberiu
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Date Issued

2024-04-01

Publisher

Elsevier

Published in
Journal Of Controlled Release
Volume

368

Start page

566

End page

579

Subjects

Physical Sciences

•

Life Sciences & Biomedicine

•

Iron Deficiency Anaemia

•

Nanoparticles (Nps)

•

Non -Biological Complex Drugs (Nbcds)

•

Iron -Carbohydrate Complexes

•

Small -Angle X-Ray Scattering (Saxs)

•

Small -Angle Neutron Scattering (Sans)

Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
CAM-X  
FunderGrant Number

CSL Vifor, Switzerland

European Union

884104

Chalmers initiative for advancement of neutron and X-ray techniques

Available on Infoscience
June 5, 2024
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/208402
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