A few months before the COVID-19 pandemic, Pierre Vogel and Kendall N. Houk published with a new textbook Wiley-VCH, "Organic Chemistry: Theory, Reactivity, and Mechanisms in Modern Synthesis", with a foreword from the late Roberts H. Grubbs. The book demonstrates how catalytic processes dominate all fields of modern organic chemistry and synthesis, and how invention combines thermodynamics, kinetics, spectroscopy, quantum mechanics, and thermochemical data libraries. Here, the authors present a few case studies that should be of interest to teachers, practitioners of organic and organometallic chemistry, and the engineers of molecules. The Vogel-Houk book is both textbook and reference manual; it provides a modern way to think about chemical reactivity and a powerful toolbox to inventors of new reactions and new procedures.