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  4. We Need Subject Matter Expertise to Choose and Identify Causal Estimands: Comment on "Estimands for Recurrent Event Endpoints in the Presence of a Terminal Event"
 
research article

We Need Subject Matter Expertise to Choose and Identify Causal Estimands: Comment on "Estimands for Recurrent Event Endpoints in the Presence of a Terminal Event"

Janvin, Matias  
•
Young, Jessica G.
•
Stensrud, Mats J.
April 3, 2023
Statistics In Biopharmaceutical Research

We summarize what we consider to be the two main limitations of the "Estimands for Recurrent Event Endpoints in the Presence of a Terminal Event" (Schmidli et al. 2022). First, the authors did not give detailed guidance on how to choose an appropriate estimand in light of subject-matter considerations. Reasoning about the mechanism by which treatment affects different types of events is central when selecting a causal estimand, and such reasoning can be grounded in the interventionist mediation literature. Second, the article also did not discuss the crucial task of identification when the aim is to study a causal question. Thereby, the authors omit important differences in the uncertainty of the assumptions needed to target each estimand by particular statistical methods. These assumptions have crucial implications for the confidence that can be placed in a given effect estimate, and for the planning and collection of relevant variables in the study design.

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Type
research article
DOI
10.1080/19466315.2022.2108138
Web of Science ID

WOS:000994061300005

Author(s)
Janvin, Matias  
Young, Jessica G.
Stensrud, Mats J.
Date Issued

2023-04-03

Publisher

TAYLOR & FRANCIS INC

Published in
Statistics In Biopharmaceutical Research
Volume

15

Issue

2

Article Number

2108138

Start page

251

End page

254

Subjects

Mathematical & Computational Biology

•

Statistics & Probability

•

Mathematics

•

causal inference

•

estimands

•

identification

•

recurrent events

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
BIOSTAT  
Available on Infoscience
June 19, 2023
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/198417
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