Wearable physiology is an expanding field, especially for sports applications that steadily require an accurate monitoring of the physical status of athletes. This work presents the co-design and the realization of an hardware front-end that enables multi-sensing of up to four endogenous electrolytes. A pH and temperature readout circuit are included for sensor calibration. The platform is validated with potassium and sodium ions monitoring. The hardware is remotely controlled by an user interface that configures the sensor panel and collects the biological data through a Bluetooth link. The sizes of the front-end circuit allows its integration into a headband, suitable for wearable monitoring in sweat.