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  4. Role of Renin-Angiotensin System in Inflammation, Immunity and Aging
 
review article

Role of Renin-Angiotensin System in Inflammation, Immunity and Aging

Capettini, Luciano S. A.
•
Montecucco, Fabrizio
•
Mach, Francois
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2012
Current Pharmaceutical Design

Recent data support the idea that the effects of RAS are not restricted to the cardiovascular and renal systems. Importantly, RAS modulates free radical production and the cellular synthesis of several molecules such as cytokines, chemokines and transcription factors. These functions reflect directly the RAS ability to modulate the cell growth, senescence and migration. Activation of the classic RAS, ACE/Ang II/AT(1)R, has been strictly related to down regulation of pro-survival genes (Nampt and Sirt3), increase in ROS production and pro-inflammatory cytokines and chemokines release, leading to cell senescence, inflammation and development of autoimmune dysfunctions. However, the new view of RAS, points to the ACE2/Ang-(1-7)/Mas receptor axis as a counter-regulator of the effects of the classic Ang II-mediated effects. This new pathway is not totally elucidated. However, some studies suggest an important role of this novel axis in the control of cytokines release as well as cell migration and synthesis, preventing extra-cellular matrix deposition and cell apoptosis. Classic RAS blockers have been proposed as anti-inflammatory and immunomodulatory agents and some studies suggest a new potential application of RAS blockers in autoimmune diseases. The aim of the present review is to update the novel roles of classical and new RAS components and their possible implication during the physiological aging, in the immune system and inflammation.

  • Details
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Type
review article
DOI
10.2174/138161212799436593
Web of Science ID

WOS:000304444500012

Author(s)
Capettini, Luciano S. A.
Montecucco, Fabrizio
Mach, Francois
Stergiopulos, Nikos  
Santos, Robson A. S.
da Silva, Rafaela F.
Date Issued

2012

Publisher

Bentham Science Publishers

Published in
Current Pharmaceutical Design
Volume

18

Start page

963

End page

970

Subjects

Renin-angiotensin

•

aging

•

immune system

•

inflammation

•

Ang II

•

Ang-(1-7)

•

Ii Type-1 Receptor

•

Smooth-Muscle-Cells

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Red Wine Polyphenols

•

Monocyte Chemoattractant Protein-1

•

Chronic Allograft Nephropathy

•

Converting Enzyme-Inhibitor

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Nitric-Oxide Synthase

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Mas-Knockout Mice

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Nf-Kappa-B

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Oxidative Stress

Editorial or Peer reviewed

NON-REVIEWED

Written at

EPFL

EPFL units
LHTC  
Available on Infoscience
June 22, 2012
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/82055
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