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review article

Fluorogenic polymethine dyes by intramolecular cyclization

Martin, Annabell  
•
Rivera-Fuentes, Pablo
June 1, 2024
Current Opinion In Chemical Biology

Fluorescence imaging plays a pivotal role in the study of biological processes, and cell -permeable fluorogenic dyes are crucial to visualize intracellular structures with high specificity. Polymethine dyes are vitally important fluorophores in singlemolecule localization microscopy and in vivo imaging, but their use in live cells has been limited by high background fluorescence and low membrane permeability. In this review, we summarize recent advances in the development of fluorogenic polymethine dyes via intramolecular cyclization. Finally, we offer an outlook on the prospects of fluorogenic polymethine dyes for bioimaging.

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Type
review article
DOI
10.1016/j.cbpa.2024.102444
Web of Science ID

WOS:001223476200001

Author(s)
Martin, Annabell  
•
Rivera-Fuentes, Pablo
Date Issued

2024-06-01

Publisher

Elsevier Sci Ltd

Published in
Current Opinion In Chemical Biology
Volume

80

Article Number

102444

Subjects

Life Sciences & Biomedicine

•

Fluorogenicity Carbocyanines Polymethine Dyes Turn-On Probes,

•

Intramolecular Cyclizations Self-Labeling Protein Tags Small-Molecule

•

Ligands Live-Cell Fluorescence Nanoscopy.

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LOCBP  
FunderGrant Number

University of Zurich

European Research Council

801572

Available on Infoscience
June 5, 2024
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/208371
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