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  4. A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response
 
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research article

A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response

Sflomos, George
•
Dormoy, Valerian
•
Metsalu, Tauno
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2016
Cancer cell

Seventy-five percent of breast cancers are estrogen receptor α positive (ER(+)). Research on these tumors is hampered by lack of adequate in vivo models; cell line xenografts require non-physiological hormone supplements, and patient-derived xenografts (PDXs) are hard to establish. We show that the traditional grafting of ER(+) tumor cells into mammary fat pads induces TGFβ/SLUG signaling and basal differentiation when they require low SLUG levels to grow in vivo. Grafting into the milk ducts suppresses SLUG; ER(+) tumor cells develop, like their clinical counterparts, in the presence of physiological hormone levels. Intraductal ER(+) PDXs are retransplantable, predictive, and appear genomically stable. The model provides opportunities for translational research and the study of physiologically relevant hormone action in breast carcinogenesis.

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Type
research article
DOI
10.1016/j.ccell.2016.02.002
Web of Science ID

WOS:000372329000017

Author(s)
Sflomos, George
•
Dormoy, Valerian
•
Metsalu, Tauno
•
Jeitziner, Rachel  
•
Battista, Laura
•
Scabia, Valentina  
•
Raffoul, Wassim
•
Delaloye, Jean-Francois
•
Treboux, Assya
•
Fiche, Maryse
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Date Issued

2016

Publisher

Elsevier

Published in
Cancer cell
Volume

29

Issue

3

Start page

407

End page

22

Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPBRI  
Available on Infoscience
April 21, 2016
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/125811
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